Preheat oven to 350°F (175°C) and grease a loaf pan.
In a large bowl, whisk together flour, sugar, baking powder, baking soda, and salt.
In another bowl, mix melted butter, orange juice, orange zest, eggs, and vanilla extract.
Gradually add the wet ingredients to the dry ingredients, stirring until just combined.
Fold in the chopped cranberries.
Pour the batter into the prepared loaf pan and smooth the top.
Bake for 50-55 minutes or until a toothpick inserted in the center comes out clean.
Let the bread cool in the pan for 10 minutes, then transfer to a wire rack to cool completely.
Optional: Drizzle with a simple glaze made of powdered sugar and orange juice before serving.