Preheat your oven to 350°F (175°C) and grease a 9x5-inch loaf pan.
In a large bowl, whisk together flour, sugar, baking powder, baking soda, and salt.
Stir in the cranberries and orange zest.
In another bowl, whisk together orange juice, melted butter, egg, and vanilla.
Gradually add the wet ingredients to the dry ingredients, stirring until just combined.
Pour the batter into the prepared loaf pan and smooth the top.
Bake for 50-55 minutes or until a toothpick inserted in the center comes out clean.
Let the bread cool in the pan for 10 minutes before transferring it to a wire rack to cool completely.